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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

SILCODE 研究中因忧虑而主观认知下降的个体的教育、APOE ɛ4 和认知

卷 18, 期 6, 2021

发表于: 30 September, 2021

页: [492 - 498] 页: 7

弟呕挨: 10.2174/1567205018666211001105425

价格: $65

摘要

背景：教育可以对主观认知衰退 (SCD) 个体的认知产生保护作用，这被认为是阿尔茨海默病 (AD) 的早期阶段。然而，教育对具有 SCD-plus 特征的 SCD 个体认知的影响尚不清楚。 目的：本研究的目的是探讨教育对具有 SCD 加特征的 SCD 个体认知的影响。 方法：共有 234 名 SCD 患者来自中国认知衰退纵向研究（SILCODE）。跨 4 个领域（记忆、执行、语言和一般认知功能）评估认知。构建多元线性回归模型来检查教育对无忧虑 (n=91) 和有忧虑 (n=143) 个体认知分数的影响。此外，我们评估了两组 APOE ε4 非携带者和 APOE ε4 携带者之间的影响差异。 结果：多元线性回归分析显示，教育对无忧虑个体的记忆、执行和语言认知以及有忧虑个体的所有认知领域都有积极影响。此外，我们发现教育对 APOE ε4 无忧虑携带者的执行认知和无忧虑 APOE ε4 携带者的语言和一般认知有积极影响。同时，教育对 APOE ε4 携带者的所有认知领域都有积极影响，焦虑的 APOE ε4 携带者的执行、语言和一般认知。 结论：这项研究表明，教育有可能延迟或减少具有 SCD 加特征的 SCD 个体的认知能力下降。

关键词: 阿尔茨海默病，主观认知能力下降，教育，认知储备，载脂蛋白 E，预防。

« Previous Next »
[1]
Sabayan B, Sorond F. Reducing risk of dementia in older age. JAMA 2017; 317(19): 2028.
[http://dx.doi.org/10.1001/jama.2017.2247] [PMID: 28510681]
[2]
Nichols E, Szoeke CEI, Vollset SE, et al. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019; 18(1): 88-106.
[http://dx.doi.org/10.1016/S1474-4422(18)30403-4] [PMID: 30497964]
[3]
World Alzheimer Report 2018. The state of the art of dementia research: New frontiers. 2018. Available from: https://www.alz.co.uk/research/world-report-2018
[4]
Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10(9): 819-28.
[http://dx.doi.org/10.1016/S1474-4422(11)70072-2] [PMID: 21775213]
[5]
Livingston G, Sommerlad A, Orgeta V, et al. Dementia prevention, intervention, and care. Lancet 2017; 390(10113): 2673-734.
[http://dx.doi.org/10.1016/S0140-6736(17)31363-6] [PMID: 28735855]
[6]
Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol 2014; 13(8): 788-94.
[http://dx.doi.org/10.1016/S1474-4422(14)70136-X] [PMID: 25030513]
[7]
Robitaille A, van den Hout A, Machado RJM, et al. Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies. Alzheimers Dement 2018; 14(4): 462-72.
[http://dx.doi.org/10.1016/j.jalz.2017.10.003] [PMID: 29396108]
[8]
Wu YT, Beiser AS, Breteler MMB, et al. The changing prevalence and incidence of dementia over time - current evidence. Nat Rev Neurol 2017; 13(6): 327-39.
[http://dx.doi.org/10.1038/nrneurol.2017.63] [PMID: 28497805]
[9]
Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 2014; 10(6): 844-52.
[http://dx.doi.org/10.1016/j.jalz.2014.01.001] [PMID: 24798886]
[10]
Rabin LA, Smart CM, Amariglio RE. Subjective cognitive decline in preclinical Alzheimer’s disease. Annu Rev Clin Psychol 2017; 13(8): 369-96.
[http://dx.doi.org/10.1146/annurev-clinpsy-032816-045136] [PMID: 28482688]
[11]
Molinuevo JL, Rabin LA, Amariglio R, et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement 2017; 13(3): 296-311.
[http://dx.doi.org/10.1016/j.jalz.2016.09.012] [PMID: 27825022]
[12]
Kielb S, Rogalski E, Weintraub S, Rademaker A. Objective features of subjective cognitive decline in a United States national database. Alzheimers Dement 2017; 13(12): 1337-44.
[http://dx.doi.org/10.1016/j.jalz.2017.04.008] [PMID: 28586648]
[13]
Lee YC, Kang JM, Lee H, et al. Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea. Alzheimers Res Ther 2020; 12(1): 52.
[http://dx.doi.org/10.1186/s13195-020-00618-1] [PMID: 32375880]
[14]
Jessen F, Amariglio RE, Buckley RF, et al. The characterisation of subjective cognitive decline. Lancet Neurol 2020; 19(3): 271-8.
[http://dx.doi.org/10.1016/S1474-4422(19)30368-0] [PMID: 31958406]
[15]
Jessen F, Wiese B, Bachmann C, et al. Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry 2010; 67(4): 414-22.
[http://dx.doi.org/10.1001/archgenpsychiatry.2010.30] [PMID: 20368517]
[16]
Jessen F, Wolfsgruber S, Wiese B, et al. AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimers Dement 2014; 10(1): 76-83.
[http://dx.doi.org/10.1016/j.jalz.2012.09.017] [PMID: 23375567]
[17]
van Harten AC, Mielke MM, Swenson-Dravis DM, et al. Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging. Neurology 2018; 91(4): e300-12.
[http://dx.doi.org/10.1212/WNL.0000000000005863] [PMID: 29959257]
[18]
Mazzeo S, Padiglioni S, Bagnoli S, et al. Assessing the effectiveness of subjective cognitive decline plus criteria in predicting the progression to Alzheimer’s disease: an 11-year follow-up study. Eur J Neurol 2020; 27(5): 894-9.
[http://dx.doi.org/10.1111/ene.14167] [PMID: 32043740]
[19]
Yang K, Chen G, Sheng C, et al. Cognitive reserve, brain reserve, APOEɛ4, and cognition in individuals with subjective cognitive decline in the SILCODE study. J Alzheimers Dis 2020; 76(1): 249-60.
[http://dx.doi.org/10.3233/JAD-200082] [PMID: 32444543]
[20]
Groot C, van Loenhoud AC, Barkhof F, et al. Differential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease. Neurology 2018; 90(2): e149-56.
[http://dx.doi.org/10.1212/WNL.0000000000004802] [PMID: 29237798]
[21]
Li X, Wang X, Su L, Hu X, Han Y. Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline. BMJ Open 2019; 9(7): e028188.
[http://dx.doi.org/10.1136/bmjopen-2018-028188] [PMID: 31350244]
[22]
Chen G, Yang K, Du W, Hu X, Han Y. Clinical characteristics in subjective cognitive decline with and without worry: baseline investigation of the SILCODE study. J Alzheimers Dis 2019; 72(2): 443-54.
[http://dx.doi.org/10.3233/JAD-190501] [PMID: 31594226]
[23]
Gifford KA, Liu D, Romano R III, Jones RN, Jefferson AL. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst) 2015; 1(4): 429-39.
[http://dx.doi.org/10.1016/j.dadm.2015.09.004] [PMID: 26878034]
[24]
Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
[http://dx.doi.org/10.1136/jnnp.23.1.56] [PMID: 14399272]
[25]
Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32(1): 50-5.
[http://dx.doi.org/10.1111/j.2044-8341.1959.tb00467.x] [PMID: 13638508]
[26]
Guo Q, Sun Y, Yu P, Hong Z, Lv C. Norm of Auditory Verbal Learning Test in the normal aged in China community. Chin J Clin Psychol 2007; 15(2): 132-4.
[27]
Zhao Q, Guo Q, Li F, Zhou Y, Wang B, Hong Z. The Shape Trail Test: application of a new variant of the Trail making test. PLoS One 2013; 8(2): e57333.
[http://dx.doi.org/10.1371/journal.pone.0057333] [PMID: 23437370]
[28]
Zhao Q, Guo Q, Hong Z. Clustering and switching during a semantic verbal fluency test contribute to differential diagnosis of cognitive impairment. Neurosci Bull 2013; 29(1): 75-82.
[http://dx.doi.org/10.1007/s12264-013-1301-7] [PMID: 23322003]
[29]
Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. Philadelphia: Lea & Febiger 1983.
[30]
Guo QH, Zhou B, Zhao QH, Wang B, Hong Z. Memory and Executive Screening (MES): a brief cognitive test for detecting mild cognitive impairment. BMC Neurol 2012; 12: 119.
[http://dx.doi.org/10.1186/1471-2377-12-119] [PMID: 23050770]
[31]
Chen KL, Xu Y, Chu AQ, et al. Validation of the Chinese version of montreal cognitive assessment basic for screening mild cognitive impairment. J Am Geriatr Soc 2016; 64(12): e285-90.
[http://dx.doi.org/10.1111/jgs.14530] [PMID: 27996103]
[32]
Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28(2): 193-213.
[http://dx.doi.org/10.1016/0165-1781(89)90047-4] [PMID: 2748771]
[33]
Stiasny-Kolster K, Mayer G, Schäfer S, Möller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument. Mov Disord 2007; 22(16): 2386-93.
[http://dx.doi.org/10.1002/mds.21740] [PMID: 17894337]
[34]
Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14(6): 540-5.
[http://dx.doi.org/10.1093/sleep/14.6.540] [PMID: 1798888]
[35]
Bondi MW, Edmonds EC, Jak AJ, et al. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimers Dis 2014; 42(1): 275-89.
[http://dx.doi.org/10.3233/JAD-140276] [PMID: 24844687]
[36]
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology 1984; 34(7): 939-44.
[http://dx.doi.org/10.1212/WNL.34.7.939] [PMID: 6610841]
[37]
Jessen F, Spottke A, Boecker H, et al. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE). Alzheimers Res Ther 2018; 10(1): 15.
[http://dx.doi.org/10.1186/s13195-017-0314-2] [PMID: 29415768]
[38]
Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002; 8(3): 448-60.
[http://dx.doi.org/10.1017/S1355617702813248] [PMID: 11939702]
[39]
Stern Y, Arenaza-Urquijo EM, Bartrés-Faz D, et al. Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement 2020; 16(9): 1305-11.
[http://dx.doi.org/10.1016/j.jalz.2018.07.219] [PMID: 30222945]
[40]
Jack CR Jr, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013; 12(2): 207-16.
[http://dx.doi.org/10.1016/S1474-4422(12)70291-0] [PMID: 23332364]
[41]
Jack CR Jr, Bennett DA, Blennow K, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement 2018; 14(4): 535-62.
[http://dx.doi.org/10.1016/j.jalz.2018.02.018] [PMID: 29653606]
[42]
Perneczky R, Kempermann G, Korczyn AD, et al. Translational research on reserve against neurodegenerative disease: consensus report of the international conference on cognitive reserve in the dementias and the Alzheimer’s association reserve, resilience and protective factors professional interest area working groups. BMC Med 2019; 17(1): 47.
[http://dx.doi.org/10.1186/s12916-019-1283-z] [PMID: 30808345]
[43]
Stern Y. Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol 2012; 11(11): 1006-12.
[http://dx.doi.org/10.1016/S1474-4422(12)70191-6] [PMID: 23079557]
[44]
Mazzeo S, Padiglioni S, Bagnoli S, et al. The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study. J Neurol 2019; 266(2): 487-97.
[http://dx.doi.org/10.1007/s00415-018-9164-5] [PMID: 30604054]
[45]
Bessi V, Mazzeo S, Padiglioni S, et al. From subjective cognitive decline to Alzheimer’s disease: the predictive role of neuropsychological assessment, personality traits, and cognitive reserve. A 7-year follow-up study. J Alzheimers Dis 2018; 63(4): 1523-35.
[http://dx.doi.org/10.3233/JAD-171180] [PMID: 29782316]
[46]
van Loenhoud AC, van der Flier WM, Wink AM, et al. Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship. Neurology 2019; 93(4): e334-46.
[http://dx.doi.org/10.1212/WNL.0000000000007821] [PMID: 31266904]

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