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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

正常衰老中认知轨迹的决定因素：基于社区的队列中的纵向PET-MRI研究

卷 18, 期 6, 2021

发表于: 30 September, 2021

页: [482 - 491] 页: 10

弟呕挨: 10.2174/1567205018666210930111806

价格: $65

摘要

背景：正常衰老中认知逐渐下降的决定因素仍然是一个有争议的问题。阿尔茨海默病（AD）特征标志物和血管病变，以及人格因素等心理变量，被认为对健康老年人神经心理表现的纵向轨迹有影响。 目的：目前的研究旨在确定与正常衰老认知轨迹相关的主要决定因素。 方法：我们对90名老年社区居民进行了为期4.5年的纵向研究，将两项神经心理学评估，内侧颞叶萎缩（MTA），脑微出血数（CMB）和白质高信号（WMH）纳入，随访时淀粉样蛋白和FDG PET的视觉评级以及APOE基因分型相结合。使用NEO-PIR在基线时评估人格因素。构建单变量和向后逐步回归模型，以探索连续认知评分（CCS）与成像和人格变量之间的关系。 结果：基线时严格肺叶CMB的数量（4个或更多）与认知能力下降风险的显著增加有关。在多变量模型中，淀粉样蛋白阳性与随访时CCS减少1.73个单位有关。MTA、WMH和异常FDG PET与认知结局无关。在人格因素中，只有更高的亲和力与更好地保存神经心理学表现有关。 结论：CMB和淀粉样蛋白阳性是这一系列高度选择的健康对照中认知轨迹的唯一成像决定因素。在人格因素中，较高的亲和力可以带来适度但显着的保护，以防止认知表现的下降。

关键词: 淀粉样蛋白、萎缩、认知、成像标记、微出血、个性。

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