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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Clinical Trial

血浆脂蛋白脂肪酶水平降低可预测中国 2 型糖尿病早期认知缺陷患者的语言不流畅

卷 18, 期 8, 2021

发表于: 21 September, 2021

页: [656 - 666] 页: 11

弟呕挨: 10.2174/1567205018666210922105850

价格: $65

摘要

背景：脂蛋白脂肪酶 (LPL) 是催化甘油三酯水解的限速酶，并有助于淀粉样蛋白-β 的形成，这有望成为 2 型糖尿病 (T2DM) 认知能力下降的病理因素。本研究旨在探讨 LPL 和 rs328 多态性在 T2DM 患者轻度认知障碍 (MCI) 中的发病机制。 方法：招募中国 T2DM 患者，根据蒙特利尔认知评估评分分为两组。收集人口统计数据，测量 LPL 并检查神经心理学测试结果。 结果：与健康认知对照组（n = 91）相比，79 名糖尿病和 MCI 患者的血浆 LPL 水平显着降低（p = 0.007）。相关分析显示，LPL与时钟绘图测试（r = 0.158，p = 0.043）和逻辑记忆测试（r = 0.162，p = 0.037）呈正相关，而脂蛋白a（r = -0.214，p = 0.006）呈负相关与 LPL 相关。 Logistic 回归分析进一步表明 LPL 浓度是糖尿病 MCI 的独立因素 (p = 0.036)。 MCI 患者和对照组之间的 rs328 变体分布未观察到显着差异。此外，在基因型亚组之间的血浆 LPL 水平、认知表现和脂质水平之间没有发现显着关联。与对照组的CC基因型相比，GC组的试验A增加。 结论：LPL 血浆水平降低可能预示早期认知缺陷，尤其是语言不流畅。

关键词: 脂蛋白脂肪酶，轻度认知障碍，执行功能，记忆功能，2 型糖尿病，rs328。

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