Abstract
This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhythmia. The preventive effects of antioxidants are documented.
Keywords: cardiovascular toxins, oxidative stress, electron transfer, lipoperoxidation, antioxidants, reactive oxygen species, radicals
Current Vascular Pharmacology
Title: Cardiovascular Toxicity from the Perspective of Oxidative Stress, Electron Transfer, and Prevention by Antioxidants
Volume: 3 Issue: 2
Author(s): Peter Kovacic and Lisa A. Thurn
Affiliation:
Keywords: cardiovascular toxins, oxidative stress, electron transfer, lipoperoxidation, antioxidants, reactive oxygen species, radicals
Abstract: This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhythmia. The preventive effects of antioxidants are documented.
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Cite this article as:
Kovacic Peter and Thurn A. Lisa, Cardiovascular Toxicity from the Perspective of Oxidative Stress, Electron Transfer, and Prevention by Antioxidants, Current Vascular Pharmacology 2005; 3 (2) . https://dx.doi.org/10.2174/1570161053586912
DOI https://dx.doi.org/10.2174/1570161053586912 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
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