A Review on Rotenoids: Purification, Characterization and its Biological Applications

Title:A Review on Rotenoids: Purification, Characterization and its Biological Applications

Volume: 21 Issue: 13

Author(s): Praveen Kumar P.K*, Priyadharshini A and Sivanandham Muthukumaran

Affiliation:

• Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur Tk - 602117, Tamilnadu,India

Keywords: Rotenoid, boeravinone, boerhaavia diffusa linn, mirabilis jalapa, abronia nana.

Abstract: Phytochemicals play a vital role as drugs for the treatment of various autoimmune, viral, and cancerous diseases. Rotenoids, a type of isoflavone compounds present in plants genus Boerhaavia sp., Mirabilis sp. and Abronia sp. which belong to the Nyctaginaceae family, are traditionally used as pesticides and insecticides. Boeravinones are groups of rotenoid compounds widely used as drugs or drug adjuvants for the treatment of various diseases. Extraction of rotenoids in various solvents, purification of rotenoids in various chromatographic technique studies, and the characterization of functional groups of rotenoids in various spectroscopic techniques have been reported. Biological applications of rotenoids such as anti-cancerous, antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities have been discussed. This review summarizes the extraction, isolation, purification, and characterization of rotenoid compounds and their effect on the treatment of cancer, inflammatory, spasmolytic, autoimmune, and microbial diseases.

Cite this article as:

P.K Kumar Praveen*, Priyadharshini A and Muthukumaran Sivanandham , A Review on Rotenoids: Purification, Characterization and its Biological Applications, Mini-Reviews in Medicinal Chemistry 2021; 21 (13) . https://dx.doi.org/10.2174/1389557521666210217092634