Abstract
Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.
Keywords: Lactoferrin, innate immunity, adaptive immunity, immunomodulation, inflammation, oxidative stress, adjuvant
Current Pharmaceutical Design
Title: Lactoferrin as a Natural Immune Modulator
Volume: 15 Issue: 17
Author(s): Jeffrey K. Actor, Shen-An Hwang and Marian L. Kruzel
Affiliation:
Keywords: Lactoferrin, innate immunity, adaptive immunity, immunomodulation, inflammation, oxidative stress, adjuvant
Abstract: Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.
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Cite this article as:
Actor K. Jeffrey, Hwang Shen-An and Kruzel L. Marian, Lactoferrin as a Natural Immune Modulator, Current Pharmaceutical Design 2009; 15 (17) . https://dx.doi.org/10.2174/138161209788453202
DOI https://dx.doi.org/10.2174/138161209788453202 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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