A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy

Title:A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy

Volume: 28 Issue: 31

Author(s): Menghua Xiang, Quanming Zhou, Zihan Shi, Xuan Wang, Mengchu Li, Yan Jia, Shaoyun Li, Fen Yang, Wei Wang, Tongkai Chen, Xiaojun Xu, Bigyan Sharma, Yichu Nie, Qicai Xiao*Liqian Gao*

Affiliation:

• School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen518107,China

• School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen518107,China

Keywords: Photodynamic therapy, photosensitizers, reactive oxygen species (ROS), light source, oncotherapy, targeting.

Abstract: Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual-selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.

Cite this article as:

Xiang Menghua , Zhou Quanming , Shi Zihan, Wang Xuan , Li Mengchu , Jia Yan , Li Shaoyun, Yang Fen , Wang Wei , Chen Tongkai , Xu Xiaojun , Sharma Bigyan , Nie Yichu , Xiao Qicai*, Gao Liqian *, A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867328666210121122106