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Review Article

用于治疗目的的生物环境中的酶指示自组装

卷 26, 期 8, 2019

页: [1351 - 1365] 页: 15

弟呕挨: 10.2174/0929867324666170921104010

价格: $65

摘要

精准医学迫切需要公共医疗保健。 在过去的几十年中，纳米技术的蓬勃发展显着推动了精密纳米医学的实现。 与基于纳米颗粒的充分记录的策略相比，在本综述中，我们关注使用酶指导自组装（EISA）在生物环境中用于治疗诊断目的的策略。 原则上，EISA小分子的设计需要两个方面：（1）感兴趣的酶的底物; （2）酶促转化后的自组装效力。 该策略已显示出其在纳米片中的不可替代的优势，特别是对于癌症治疗和疫苗佐剂。 有趣的是，所有报道的实例仅依赖于一种酶水解酶。 因此，我们设想EISA策略的应用才刚刚开始，并将导致纳米医学的新范例。

关键词: 精准医学，纳米技术，酶，自组装，治疗学，疫苗佐剂。

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