Generic placeholder image

Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides

Author(s): Nguyen-Hai Nam, Phan Thi Phuong Dung, Doan Thanh Hieu, Le Hoang, Tran Thi Hien, Tran The Cuong and Phan Dinh Chau

Volume 7, Issue 6, 2011

Page: [727 - 731] Pages: 5

DOI: 10.2174/157340611797928280

Price: $65

Abstract

A series of simple (6-substitutedbenzothiazol-2-yl)acrylamides was synthesized and evaluated for cytotoxicity and antimicrobial effects. All six compounds displayed very significant cytotoxicity against four cancer cell lines tested including A549 (a human lung cancer cell line), Hela (a human ovarian cancer cell line), MCF7 (a human breast cancer cell line), and even MCF7-ADR (adriamycin-resistant human breast cancer cell line), with IC50 values in microgram/ml range and as low as 0.66 μg/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger.

Keywords: kwd, Benzothiazole, cytotoxicity, synthesis, acrylamides, (6-substitutedbenzothiazol-2-yl), and antimicrobial effects, antifungal effects, Apergillus niger, nucleophilic, 2-aminobenzothiazole

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy