Generic placeholder image

Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Cancer Chemoprevention by Dietary Phytochemicals: Promises and Pitfalls

Author(s): Ramamurthi Vidya Priyadarsini and Siddavaram Nagini

Volume 13, Issue 1, 2012

Page: [125 - 136] Pages: 12

DOI: 10.2174/138920112798868610

Price: $65

Abstract

Research over the past decade has provided convincing evidence to support the premise that phytochemicals from the diet offer protection against cancer risk. A large number of dietary phytochemicals have been demonstrated to exhibit anticancer activities by interfering with multiple signaling pathways aberrant in cancer. These agents target a plethora of cellular molecules and molecular pathways including xenobiotic-metabolizing enzymes, reactive oxygen species, inflammation, cell cycle, apoptosis, invasion, angiogenesis, transcription factors, and protein kinases. In addition, dietary phytochemicals also synergize with conventional chemotherapy and radiotherapy. Thus naturally derived phytochemicals could play an important role in cancer chemoprevention and therapy owing to multitargeted mechanistic action and lack of substantial toxicity. However, more rationally designed novel clinical trials are required to translate the preclinical findings into tangible clinical benefits

Keywords: Chemoprevention, dietary agents, molecular targets, multitargeted prevention, phytochemicals, cancer, plethora of cellular molecules, xenobiotic-metabolizing enzymes, reactive oxygen species, inflammation, apoptosis, invasion, angiogenesis, transcription factors, protein kinases


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy