Nanosuspension: Principles, Perspectives and Practices

Title:Nanosuspension: Principles, Perspectives and Practices

Volume: 13 Issue: 8

Author(s): Sachin Kumar Singh, Yogyata Vaidya, Monica Gulati, Sibasis Bhattacharya, Varun Garg and Narendra Kumar Pandey

Affiliation:

Keywords: Bottom up technology, Characterization, High pressure homogenization, Media milling, Nanosuspension, Stability.

Abstract: In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose. The unique inherent properties of nanosuspensions have been explored for a wide variety of applications. Commercial production of stable nanosuspensions has been made possible by the use of techniques such as media milling and high pressure homogenization. This article reviews various techniques being employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to overcome their stability and commercialization related aspects are also highlighted.

Cite this article as:

Singh Kumar Sachin, Vaidya Yogyata, Gulati Monica, Bhattacharya Sibasis, Garg Varun and Pandey Kumar Narendra, Nanosuspension: Principles, Perspectives and Practices, Current Drug Delivery 2016; 13 (8) . https://dx.doi.org/10.2174/1567201813666160101120452