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Review Article

Role of Polysaccharides Mimetic Components in Targeted Cancer Treatment

Author(s): Nandan Gupta and Rishabha Malviya*

Volume 23, Issue 9, 2022

Published on: 18 April, 2022

Page: [856 - 868] Pages: 13

DOI: 10.2174/1389450123666220214121505

Price: $65

Abstract

Organic or inorganic compounds are synthesized or formulated to demonstrate their therapeutic actions, like a natural polysaccharide in the body. Polysaccharides, the major type of natural polymers, are biologically active, non-toxic, hydrophilic, and biodegradable and exhibit various properties. This manuscript is focused on delivering anticancer drugs with the help of mimetic components of polysaccharides. The data presented in this manuscript were obtained from PubMed, Elsevier, Taylor & Francis and Bentham Science Journals. Most chemotherapeutics are toxic to the human body, have a narrow therapeutic index, sluggish pharmaceutical delivery mechanisms, and are poorly soluble in water. The use of mimetic components of polysaccharides leads to the enhancement of the solubility of drugs in the biological environment. The current review summarizes the use of mimetic components of polysaccharides along with anticancer agents, which are capable of inhibiting the growth of cancerous cells in the body and exhibiting lesser adverse effects in the biological system compared to other therapies.

Keywords: Polysaccharide, cancer, drug delivery, nanoformulations, therapy, mimetic components.

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