Abstract
Comparative genomic in situ hybridization (CGH) studies have marked regions of unbalanced genomic alterations in a variety of human solid and hematological malignancies. Subsequent molecular analysis helped to pinpoint genes contributing to tumorigenic development and progression. CGH has since become a routine tool in molecular diagnostics and cancer research. Since mice and rats represent major model systems for human malignancies, CGH was soon adapted for tracing DNA copy number changes in experimental rodent tumor genomes. A stronghold of this approach is the potential transfer of information to the human situation by use of comparative maps of mouse and rat, and the human genome. This allows for an evaluation and validation of rodent tumor models at the genomic level. This review will illuminate the insights obtained by CGH analysis of rodent tumor genomes and the comparative transfer of this information between rodents and human.
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
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