Abstract
The testis is devoted to two important tasks: haploid cell production and sexual steroid synthesis. A number of highly sophisticated and unique strategies operate during spermatogenesis, a process crucial for reproduction, heredity and evolution. It is particularly important to decipher the underlying molecular mechanisms whose function can be perverted in pathological situations, such as infertility and testicular cancers, which represent an increasing biomedical issue today. This review summarises the currently available data concerning some key molecular components that are altered or potentially involved in male infertility and testicular tumors, with the aim of defining some common “hot spots”. We particularly focused on genetically engineered in vivo models in which testicular functions are altered and we pinpointed to the potential involvement of the targeted genes in testicular pathologies. Those molecular mechanisms peculiar to the male gonad can be envisioned as a basis for the design of novel drugs potentially dedicated to testicular dysfunction.
Keywords: testis, infertility, cancer, human, reproduction
Current Pharmaceutical Design
Title: A Mechanistic Overview on Male Infertility and Germ Cell Cancers
Volume: 10 Issue: 5
Author(s): Pascale Crepieux, Charlotte Lecureuil, Sebastien Marion, Elodie Kara, Vincent Piketty, Nadine Martinat, Florian Guillou, Dominique Royere and Eric Reiter
Affiliation:
Keywords: testis, infertility, cancer, human, reproduction
Abstract: The testis is devoted to two important tasks: haploid cell production and sexual steroid synthesis. A number of highly sophisticated and unique strategies operate during spermatogenesis, a process crucial for reproduction, heredity and evolution. It is particularly important to decipher the underlying molecular mechanisms whose function can be perverted in pathological situations, such as infertility and testicular cancers, which represent an increasing biomedical issue today. This review summarises the currently available data concerning some key molecular components that are altered or potentially involved in male infertility and testicular tumors, with the aim of defining some common “hot spots”. We particularly focused on genetically engineered in vivo models in which testicular functions are altered and we pinpointed to the potential involvement of the targeted genes in testicular pathologies. Those molecular mechanisms peculiar to the male gonad can be envisioned as a basis for the design of novel drugs potentially dedicated to testicular dysfunction.
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Crepieux Pascale, Lecureuil Charlotte, Marion Sebastien, Kara Elodie, Piketty Vincent, Martinat Nadine, Guillou Florian, Royere Dominique and Reiter Eric, A Mechanistic Overview on Male Infertility and Germ Cell Cancers, Current Pharmaceutical Design 2004; 10 (5) . https://dx.doi.org/10.2174/1381612043453270
DOI https://dx.doi.org/10.2174/1381612043453270 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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