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Current HIV Research

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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Pivotal Role of the Genital Epithelial Cells in HIV-1 Transmission

Author(s): Amelie De Saint Jean, Thomas Bourlet and Olivier Delezay

Volume 13, Issue 6, 2015

Page: [479 - 489] Pages: 11

DOI: 10.2174/1570162X13666150624100339

Price: $65

Abstract

AIDS remains one of the world’s most serious health challenges, with 35 million people living with HIV worldwide at the end of 2013. HIV sexual transmission accounts for the overwhelming majority of people newly infected, making genital and rectal mucosal tissues the major sites of infection. This review focuses on the role of the female genital epithelial cells in the establishment of HIV infection.

Keywords: Epithelial cells, female genital tract, HIV-1, innate immunity, microbicides, semen, sexually transmitted agents.

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