New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

Title:New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

Volume: 22 Issue: 10

Author(s): Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang

Affiliation:

Keywords: Granulocyte-colony stimulating factor, neuroprotection, stroke, treatment.

Abstract: Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Cite this article as:

Solaroglu Ihsan, Digicaylioglu Murat, Keles Evren G. and Zhang H. John, New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150209153606