MicroRNAs:与作为绿色基因治疗途径的自然疗法潜在放射性用途之间的联系

Title:MicroRNAs: Association with Radioresistant and Potential Uses of Natural Remedies as Green Gene Therapeutic Approaches

Volume: 15 Issue: 1

Author(s): Subramanion L. Jothy, Yeng Chen, Soundararajan Vijayarathna, Jagat R. Kanwar and Sreenivasan Sasidharan

Affiliation:

关键词: 基因治疗，miRNAs，自然疗法，辐射防护药品，抗辐射性，肿瘤复发

摘要: Radiotherapy plays an essential primary role in cancer patients. Regardless of its significant advances in treatment options, tumor recurrence and radio-resistance in cancer cells still occur in a high percentage of patients. Furthermore, the over expression of miRNAs accompanies the development of radio-resistant cancer cells. Consequently, miRNAs might serve as therapeutic targets for the treatment of radio-resistance in cancer cells. The findings of the current research also signify that the use of a natural anti-miRNA substance could inhibit specific miRNAs, and, concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy. Therefore, in this review, we have reported the association of miRNAs with radio-resistance and the potential uses of natural remedies as green gene therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation on healthy cells during radiotherapy.

Cite this article as:

Subramanion L. Jothy, Yeng Chen, Soundararajan Vijayarathna, Jagat R. Kanwar and Sreenivasan Sasidharan , MicroRNAs: Association with Radioresistant and Potential Uses of Natural Remedies as Green Gene Therapeutic Approaches, Current Gene Therapy 2015; 15 (1) . https://dx.doi.org/10.2174/1566523215666141205104117