Natural Polymers Based Hydrogels for Cell Culture Applications

doi:10.2174/0929867326666190903113004
摘要

细胞外基质(extracellular matrix, ECM)在细胞的生长、存活和分化中起着至关重要的作用。尽管二维(2D)材料通常被用作标准体外实验的基质，但它们的机械、结构和成分特征可以彻底改变细胞功能。许多科学家报告说，细胞在三维(3D)环境中培养时比在二维基质上表现得更自然，因为三维细胞培养环境更像活体，可以更好地模拟ECM的生化和机械特性。在这方面，水膨胀网络聚合物材料称为水凝胶，由于其生物相容性和亲水性，在开发3D ECM类似物方面具有很大的吸引力。由于水凝胶可以被系统地调节和改变，这些材料可以在特定的培养基中活跃地发挥作用，以支持各种细胞的长期自我更新。开发水凝胶材料的物理化学和生物特性应根据培养需要进行调整。各种类型的水凝胶，无论是天然的或合成的来源，目前正在用于细胞培养应用。在这篇综述中，我们概述了各种基于天然聚合物的水凝胶，可用于细胞培养，无论应用类型。我们还解释了每一种水凝胶是如何制造的，它的来源，在生物应用中的利弊，特别关注再生工程。
关键词: 水凝胶
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DOI https://dx.doi.org/10.2174/0929867326666190903113004	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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