Modulation of MMPs by Cell Surface Integrin Receptor α5β1

Title:Modulation of MMPs by Cell Surface Integrin Receptor α5β1

Volume: 12 Issue: 7

Author(s): Sekhar Pal, Kirat Kumar Ganguly, Shuvojit Moulik and Amitava Chatterjee

Affiliation:

Keywords: ECM, Fibronectin, Integrin, MMP, extracellular matrix, matrix metalloproteinase, membrane-type-1 MMP, tissue inhibitor of metalloproteinases, focal adhesion kinase, phosphatidyl-inositol-3-kinase, mitogen activated protein kinase, extracellular regulated kinase.

Abstract: MMPs are a family of Zn dependent endopeptidases, which can mediate degradation of ECM components during various physiological and pathological processes including cancer. Some ECM components, through interaction with integrin receptor and modulation of downstream signaling, are capable of regulating expression and activity of several MMPs. α5β1 integrin is the universally accepted receptor for the ECM component fibronectin (FN). The present review deals with the downstream signaling involved in the α5β1 integrin mediated modulation of expression and activity of MMPs and their effector responses in different cellular system.

Cite this article as:

Pal Sekhar, Kumar Ganguly Kirat, Moulik Shuvojit and Chatterjee Amitava, Modulation of MMPs by Cell Surface Integrin Receptor α5β1, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (7) . https://dx.doi.org/10.2174/187152012802650183