Abstract
The industrial synthesis of pharmaceutical compounds often involves the use of organic solvents. Unfortunately, these reaction media are responsible for organic contaminations in the final product. In recent years, ionic liquids (ILs) have become the “green alternatives” of volatile organic solvents. Thus, the application of ILs instead of conventional reagents offer a new opportunity to solve problems of environmentally harmful solvents. This mini-review discusses a new application of ILs in laboratory-scale pharmaceutical synthesis.
Keywords: Active pharmaceutical ingredient, biocatalytic reaction, green chemistry, ionic liquid, RTILs, antiparasitic drugs, DMAP, NSAIDs, CPPO, BNCT, Prvadoline
Mini-Reviews in Organic Chemistry
Title:Ionic Liquids: A New Strategy in Pharmaceutical Synthesis
Volume: 9 Issue: 2
Author(s): Tomasz Siodmiak, Michal Piotr Marszall and Anna Proszowska
Affiliation:
Keywords: Active pharmaceutical ingredient, biocatalytic reaction, green chemistry, ionic liquid, RTILs, antiparasitic drugs, DMAP, NSAIDs, CPPO, BNCT, Prvadoline
Abstract: The industrial synthesis of pharmaceutical compounds often involves the use of organic solvents. Unfortunately, these reaction media are responsible for organic contaminations in the final product. In recent years, ionic liquids (ILs) have become the “green alternatives” of volatile organic solvents. Thus, the application of ILs instead of conventional reagents offer a new opportunity to solve problems of environmentally harmful solvents. This mini-review discusses a new application of ILs in laboratory-scale pharmaceutical synthesis.
Export Options
About this article
Cite this article as:
Siodmiak Tomasz, Piotr Marszall Michal and Proszowska Anna, Ionic Liquids: A New Strategy in Pharmaceutical Synthesis, Mini-Reviews in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157019312800604698
DOI https://dx.doi.org/10.2174/157019312800604698 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phytochemical Characterization of Prickly Pear (Opuntia spp.) and of its Nutritional and Functional Properties: A Review
Current Nutrition & Food Science Probing the Phosphopeptide Specificities of Protein Tyrosine Phosphatases, SH2 and PTB Domains with Combinatorial Library Methods
Current Protein & Peptide Science Sauropus androgynus Leaves for Health Benefits: Hype and the Science
The Natural Products Journal Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
Current Drug Metabolism Diversity and Variability of the Effects of Nicotine on Different Cortical Regions of the Brain. Therapeutic and Toxicological Implications
Central Nervous System Agents in Medicinal Chemistry Recent Advances in Bipolar Electrochemiluminescence for Analytical Application
Current Analytical Chemistry Molecular and Genetic Characterization of Natural Variants of HIV-1 Nef Gene from North India and its Functional Implication in Down-Regulation of MHC-I and CD-4
Current HIV Research The Urokinase Receptor as a Potential Target in Cancer Therapy
Current Pharmaceutical Design Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics
Current Molecular Pharmacology Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives
Anti-Cancer Agents in Medicinal Chemistry Evaluation of Alkylating and Intercalating Properties of Mannich Bases for Cytotoxic Activity
Letters in Drug Design & Discovery Vitamin D Insufficiency and Diabetes Risks
Current Drug Targets HPLC Stability Indicating Assay Method for Metformin Hydrochloride in Bulk Drug and Tablets and Cytotoxicity of Degradation Products
Current Pharmaceutical Analysis Mechanical Imaging - a Technology for 3-D Visualization and Characterization of Soft Tissue Abnormalities: A Review
Current Medical Imaging Importance of Influx and Efflux Systems and Xenobiotic Metabolizing Enzymes in Intratumoral Disposition of Anticancer Agents
Current Cancer Drug Targets Current Experimental, Bioinformatic and Statistical Methods used in NMR Based Metabolomics
Current Metabolomics Plant Sterols and Stanols as Cholesterol-Lowering Ingredients in Functional Foods
Recent Patents on Food, Nutrition & Agriculture The Shielding Action of Disaccharides for Typical Proteins in Aqueous Solution Against Static, 50 Hz and 1800 MHz Frequencies Electromagnetic Fields
Current Chemical Biology Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles
Letters in Drug Design & Discovery Cyclopamine, a Naturally Occurring Alkaloid, and Its Analogues May Find Wide Applications in Cancer Therapy
Current Topics in Medicinal Chemistry