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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity

Author(s): Marina Sagnou, Alexandros Strongilos, Dimitra Hadjipavlou-Litina and Elias A. Couladouros

Volume 6, Issue 3, 2009

Page: [172 - 177] Pages: 6

DOI: 10.2174/157018009787847792

Price: $65

Abstract

Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.

Keywords: Shikonin, Inflammation, Psoriasis, LOX, Radical scavengers, Benzoquinones


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