Abstract
Distal embolization (DE) can be either spontaneous or iatrogenic, occurring during percutaneous coronary intervention (PCI). The nature, composition and biochemical properties of embolized material differ according to the setting in which DE occurs: acute coronary syndromes (ACS) or stable coronary artery disease (CAD). DE occurrence is related to increased cardiac biomarkers, negative left ventricular remodeling and associated with a poor prognosis. Prevention and treatment of DE represent some of the most debated topics in interventional cardiology. This review paper is focused on mechanisms of DE and on the strategies for its prevention and treatment in both ACS and stable CAD.
Keywords: Distal embolization, microvascular obstruction, thrombus aspiration, protection devices, antiplatelet agents.
Current Pharmaceutical Design
Title:Mechanisms, Prevention and Treatment of Distal Embolization
Volume: 19 Issue: 25
Author(s): Italo Porto, Giovanni Luigi De Maria, Maurizio Pieroni, Leonardo Bolognese and Filippo Crea
Affiliation:
Keywords: Distal embolization, microvascular obstruction, thrombus aspiration, protection devices, antiplatelet agents.
Abstract: Distal embolization (DE) can be either spontaneous or iatrogenic, occurring during percutaneous coronary intervention (PCI). The nature, composition and biochemical properties of embolized material differ according to the setting in which DE occurs: acute coronary syndromes (ACS) or stable coronary artery disease (CAD). DE occurrence is related to increased cardiac biomarkers, negative left ventricular remodeling and associated with a poor prognosis. Prevention and treatment of DE represent some of the most debated topics in interventional cardiology. This review paper is focused on mechanisms of DE and on the strategies for its prevention and treatment in both ACS and stable CAD.
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Cite this article as:
Porto Italo, Maria De Giovanni Luigi, Pieroni Maurizio, Bolognese Leonardo and Crea Filippo, Mechanisms, Prevention and Treatment of Distal Embolization, Current Pharmaceutical Design 2013; 19 (25) . https://dx.doi.org/10.2174/1381612811319250006
DOI https://dx.doi.org/10.2174/1381612811319250006 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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