Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

Title:Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

Volume: 9 Issue: 2

Author(s): Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony and Ahmed A. M. El-Reedy

Affiliation:

Keywords: Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.

Abstract: A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.

Cite this article as:

Attaby A. Fawzy., El-Ghandour H. Ahmed, Sayed R. Abdelwahed, El Bassuony A. Ashraf and El-Reedy A. M. Ahmed, Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides, Current Bioactive Compounds 2013; 9 (2) . https://dx.doi.org/10.2174/15734072113099990011