Abstract
There has long been a concern that all psychotropics may have adverse cardiac effects including prolongation of the QT interval. The recent expanded use of the atypical antipsychotics has increased these concerns. This is a selective review of the effect of the major classes of psychotropic drugs on the QT interval. The review also includes a review of methadone given the high co-morbidity between major psychiatric disorders and substance use disorders.
Keywords: Acquired LQTS, drug-induced QT syndrome, methadone, psychiatry, psychotropics, QT interval, QT prolongation, sudden cardiac death, cardiometabolic risk, arrhythmogenic, mesoridazine, phenothiazines, hypomagnesemia, epidemiologic, tachyarrhythmias
Current Psychopharmacology
Title: Psychotropics and Methadone in Acquired Long QT Syndrome
Volume: 1
Author(s): Stephan Carlson and Russell Joffe
Affiliation:
Keywords: Acquired LQTS, drug-induced QT syndrome, methadone, psychiatry, psychotropics, QT interval, QT prolongation, sudden cardiac death, cardiometabolic risk, arrhythmogenic, mesoridazine, phenothiazines, hypomagnesemia, epidemiologic, tachyarrhythmias
Abstract: There has long been a concern that all psychotropics may have adverse cardiac effects including prolongation of the QT interval. The recent expanded use of the atypical antipsychotics has increased these concerns. This is a selective review of the effect of the major classes of psychotropic drugs on the QT interval. The review also includes a review of methadone given the high co-morbidity between major psychiatric disorders and substance use disorders.
Export Options
About this article
Cite this article as:
Carlson Stephan and Joffe Russell, Psychotropics and Methadone in Acquired Long QT Syndrome, Current Psychopharmacology 2012; 1 (2) . https://dx.doi.org/10.2174/2211556011201020183
DOI https://dx.doi.org/10.2174/2211556011201020183 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Biomarkers of Atrial Fibrillation in Hypertension
Current Medicinal Chemistry Effects of Hypertension, Diabetes Mellitus, Obesity and Other Factors on Kidney Haemodynamics
Current Vascular Pharmacology Patented Small Molecules Used for Reprogramming
Recent Patents on Regenerative Medicine Substance-Related Disorders and Somatic Symptoms: How Should Clinicians Understand the Associations?
Current Drug Abuse Reviews Genistein as a Potential Anticancer Agent Against Head and Neck Squamous Cell Carcinoma
Current Topics in Medicinal Chemistry The Etiology of Hypertension in the Metabolic Syndrome Part Two: The Gene-Environment Interaction
Current Vascular Pharmacology N-Containing Ag(I) and Hg(II) Complexes: A New Class of Antibiotics
Current Topics in Medicinal Chemistry Mutations of mtDNA in some Vascular and Metabolic Diseases
Current Pharmaceutical Design Transmucosal Delivery of Linagliptin for the Treatment of Type- 2 Diabetes Mellitus by Ultra-Thin Nanofibers
Current Drug Delivery Racial Differences in Gray Matter Integrity by Diffusion Tensor in Black and White Octogenarians
Current Alzheimer Research The Use of Exercise Echocardiography in the Evaluation of Mitral Regurgitation
Current Cardiology Reviews Activity Based Chemical Proteomics: Profiling Proteases as Drug Targets
Current Drug Discovery Technologies A Therapeutic Target of Cerebral Hemorrhagic Stroke: Matrix Metalloproteinase- 9
Current Drug Targets Application of Metabolomics in Drug Discovery, Development and Theranostics
Current Metabolomics Critical Questions for Preclinical Trials on Safety and Efficacy of Vascular Endothelial Growth Factor-Based Therapeutic Angiogenesis for Ischemic Stroke
CNS & Neurological Disorders - Drug Targets Pleiotropic Beneficial Effects of Epigallocatechin Gallate, Quercetin and Delphinidin on Cardiovascular Diseases Associated with Endothelial Dysfunction
Cardiovascular & Hematological Agents in Medicinal Chemistry Serum Uric Acid and Diabetes: From Pathophysiology to Cardiovascular Disease
Current Pharmaceutical Design Vascular Lesion Thickness in the Lenticulostriate Artery Region Serves as a Biomarker for Early Neurological Deterioration
Current Neurovascular Research Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
Current Genomics Mitochondrial Aldehyde Dehydrogenase, A Potential Drug Target for Protection of Heart and Brain from Ischemia/Reperfusion Injury
Current Drug Targets