Vascular Lesion Thickness in the Lenticulostriate Artery Region Serves as a Biomarker for Early Neurological Deterioration

Title:Vascular Lesion Thickness in the Lenticulostriate Artery Region Serves as a Biomarker for Early Neurological Deterioration

Volume: 14 Issue: 3

Author(s): Yuan Gao, Bo Song , Lu Zhao , Hui Fang , Yan Ji, Quan Yong, Zhengrong Wu and Yuming Xu*

Affiliation:

• Department of Neurology, the first Affiliated Hospital of Zhengzhou University, No.1 Jian-she East Road, Zhengzhou, 450052, Henan,China

Keywords: Subcortical infarction, lesion pattern, early neurological deterioration, DWI, LSA, MRI.

Abstract: Background: Early neurological deterioration (END) was common in single small subcortical infarction (SSSI). Distal type of SSSI (dSSSI) was reported to have a lower risk of END than proximal type of SSSI (pSSSI) in lenticulostriate artery(LSA) territory. However, dSSSIs with different lesion thickness might have different risks of END.

Objective: In this prospective cohort study, we aimed to investigate whether dSSSIs visible on ≥3 serial axial diffusion weighted imaging (DWI) slices were also imaging markers for END.

Methods: Patients of SSSIs in the LSA territory admitted within 72 hours from the onset were selected in a prospective stroke database. Clinical characteristics including the occurrence of END after admission were recorded. The lowest slice (LS), total number of slices (TNS) involved and the maximum axial diameter were evaluated for lesion location and size on axial plane of DWI images. Lesion patterns were categorized according to LS and TNS. Multivariate logistic analysis was performed to determine the imaging pattern that associated with END.

Results: A total of 201 out of 1,158 patients were analyzed. END occurred in 32(15.9%) patients after admission. SSSI was categorized to pSSSI (LS≤2), distal and large SSSI (dl-SSSI, LS>2, TNS≥3), distal and small SSSI (ds-SSSI, LS>2, TNS<3) respectively. Multivariate logistic analysis showed that ds-SSSI patients had a significantly lower rate of END(OR 0.20, 95% CI 0.06-0.71, P=0.013) comparing to dl-SSSI patients; pSSSI patients, however, had a similar rate of END (OR 1.27, 95% CI 0.50-3.21, P=0.611) to dl-SSSI patients.

Conclusion: Except for pSSSI, dl-SSSI was also an imaging marker for END in the territory of LSA.

Cite this article as:

Gao Yuan, Song Bo , Zhao Lu , Fang Hui , Ji Yan, Yong Quan , Wu Zhengrong and Xu Yuming*, Vascular Lesion Thickness in the Lenticulostriate Artery Region Serves as a Biomarker for Early Neurological Deterioration, Current Neurovascular Research 2017; 14 (3) . https://dx.doi.org/10.2174/1567202614666170621104824

DOI https://dx.doi.org/10.2174/1567202614666170621104824	Print ISSN 1567-2026
Publisher Name Bentham Science Publisher	Online ISSN 1875-5739