Abstract
The G-protein coupled receptors - or GPCRs - comprise simultaneously one of the largest and one of the most multi-functional protein families known to modern-day molecular bioscience. From a drug discovery and pharmaceutical industry perspective, the GPCRs constitute one of the most commercially and economically important groups of proteins known. The GPCRs undertake numerous vital metabolic functions and interact with a hugely diverse range of small and large ligands. Many different methodologies have been developed to efficiently and accurately classify the GPCRs. These range from motif-based techniques to machine learning as well as a variety of alignment-free techniques based on the physiochemical properties of sequences. We review here the available methodologies for the classification of GPCRs. Part of this work focuses on how we have tried to build the intrinsically hierarchical nature of sequence relations, implicit within the family, into an adaptive approach to classification. Importantly, we also allude to some of the key innate problems in developing an effective approach to classifying the GPCRs: the lack of sequence similarity between the six classes that comprise the GPCR family and the low sequence similarity to other family members evinced by many newly revealed members of the family.
Keywords: GPCR, classification, bioinformatics, alignment, tools, modern-day molecular bioscience., drug discovery, ligands, motif-based techniques, alignment-free techniques, the lack of sequence similarity between the six classes, low sequence similarity, global proteome, data-hungry informatics analysis, informatics-led discovery
Current Topics in Medicinal Chemistry
Title: Present Perspectives on the Automated Classification of the G-Protein Coupled Receptors (GPCRs) at the Protein Sequence Level
Volume: 11 Issue: 15
Author(s): Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Jon Timmis and Darren R. Flower
Affiliation:
Keywords: GPCR, classification, bioinformatics, alignment, tools, modern-day molecular bioscience., drug discovery, ligands, motif-based techniques, alignment-free techniques, the lack of sequence similarity between the six classes, low sequence similarity, global proteome, data-hungry informatics analysis, informatics-led discovery
Abstract: The G-protein coupled receptors - or GPCRs - comprise simultaneously one of the largest and one of the most multi-functional protein families known to modern-day molecular bioscience. From a drug discovery and pharmaceutical industry perspective, the GPCRs constitute one of the most commercially and economically important groups of proteins known. The GPCRs undertake numerous vital metabolic functions and interact with a hugely diverse range of small and large ligands. Many different methodologies have been developed to efficiently and accurately classify the GPCRs. These range from motif-based techniques to machine learning as well as a variety of alignment-free techniques based on the physiochemical properties of sequences. We review here the available methodologies for the classification of GPCRs. Part of this work focuses on how we have tried to build the intrinsically hierarchical nature of sequence relations, implicit within the family, into an adaptive approach to classification. Importantly, we also allude to some of the key innate problems in developing an effective approach to classifying the GPCRs: the lack of sequence similarity between the six classes that comprise the GPCR family and the low sequence similarity to other family members evinced by many newly revealed members of the family.
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Cite this article as:
N. Davies Matthew, E. Gloriam David, Secker Andrew, A. Freitas Alex, Timmis Jon and R. Flower Darren, Present Perspectives on the Automated Classification of the G-Protein Coupled Receptors (GPCRs) at the Protein Sequence Level, Current Topics in Medicinal Chemistry 2011; 11 (15) . https://dx.doi.org/10.2174/156802611796391221
DOI https://dx.doi.org/10.2174/156802611796391221 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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