Abstract
Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by pathogens and tumors to establish chronic infections or to promote tumor survival. In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging.
Keywords: Inhibitory, T cell, CTLA-4, PD-1
Current Pharmaceutical Design
Title: The Use of the Inhibitory Receptors for Modulating the Immune Responses
Volume: 14 Issue: 26
Author(s): S. M. Henson, R. Macaulay, S. Kiani-Alikhan and A. N. Akbar
Affiliation:
Keywords: Inhibitory, T cell, CTLA-4, PD-1
Abstract: Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by pathogens and tumors to establish chronic infections or to promote tumor survival. In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging.
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Cite this article as:
Henson M. S., Macaulay R., Kiani-Alikhan S. and Akbar N. A., The Use of the Inhibitory Receptors for Modulating the Immune Responses, Current Pharmaceutical Design 2008; 14 (26) . https://dx.doi.org/10.2174/138161208786264124
DOI https://dx.doi.org/10.2174/138161208786264124 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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