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Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

Chronic Pain: Cytokines, Lymphocytes and Chemokines

Author(s): Marcia de Miguel, Durval Campos Kraychete and Roberto Jose Meyer Nascimento

Volume 13, Issue 5, 2014

Page: [339 - 349] Pages: 11

DOI: 10.2174/1871528114666150114170004

Price: $65

Abstract

Chronic pain is a debilitating condition and, in most cases, difficult to treat. A prominent example of this is neuropathic pain. Understanding pathophysiological mechanisms of pain and, therefore, making this knowledge into an effective treatment is still a challenge to experts. Pain can now be considered as a neuro-immune disorder, since recent data indicate critical involvement of innate and adaptive immune responses following injury, and this interaction plays an important role in the onset and perpetuation of chronic pain. The aim of this article is to review the relationship between immune system and chronic pain, especially about neuropathic pain, and focusing on cytokines, chemokines and lymphocytes.

Keywords: Chemokines, chronic pain, cytokines, immune system, lymphocytes.

Graphical Abstract


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