Abstract
Neuronal degeneration is closely associated with cognitive, motor and visual dysfunctions. Neuroprotective strategies have been investigated with the view to being employed as potential therapy for patients with these disabilities. Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons. These observations raise the possibility that application of PEDF may be helpful in designing new therapeutic strategies for neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinsons disease, Huntingtons disease, Alzheimers disease and brain ischemia.
Keywords: Pigment epithelium-derived factor, neuroprotection, CNS neurons, neurodegenerative disease, ischemia, NF-κB, apoptosis inducing factor
Current Molecular Medicine
Title: The Neuroprotective Role of PEDF: Implication for the Therapy of Neurological Disorders
Volume: 10 Issue: 3
Author(s): T. Yabe, T. Sanagi and H. Yamada
Affiliation:
Keywords: Pigment epithelium-derived factor, neuroprotection, CNS neurons, neurodegenerative disease, ischemia, NF-κB, apoptosis inducing factor
Abstract: Neuronal degeneration is closely associated with cognitive, motor and visual dysfunctions. Neuroprotective strategies have been investigated with the view to being employed as potential therapy for patients with these disabilities. Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons. These observations raise the possibility that application of PEDF may be helpful in designing new therapeutic strategies for neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinsons disease, Huntingtons disease, Alzheimers disease and brain ischemia.
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Cite this article as:
Yabe T., Sanagi T. and Yamada H., The Neuroprotective Role of PEDF: Implication for the Therapy of Neurological Disorders, Current Molecular Medicine 2010; 10 (3) . https://dx.doi.org/10.2174/156652410791065354
DOI https://dx.doi.org/10.2174/156652410791065354 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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