Abstract
Hepatocyte growth factor (HGF) has been shown to have multiple effects on the wound healing process. Several in vitro and ex vivo models using HGF have been shown to promote wound healing. The expression of HGF and its receptor cMet are different in chronic and acute wounds. HGF treatments in chronic wounds have not lived up to the expectations of the in vitro and ex vivo models. This review looks at the different expression of the HGF receptor and HGF agonists in chronic wounds compared to acute wounds. This aberrant expression may have a value in identifying early the wounds at risk of becoming chronic. A greater understanding of HGF and HGF agonists expression will have a direct implication for a protein engineering approach to the management of chronic wounds.
Keywords: HGF, HGF agonists, c-Met, wound healing, Matriptase, Keratinocyte, proteolytic
Current Signal Transduction Therapy
Title: HGF and HGF Agonists, Expression in Wound and Potential Role in the Management of Wound Healing
Volume: 6 Issue: 2
Author(s): Kevin Conway
Affiliation:
Keywords: HGF, HGF agonists, c-Met, wound healing, Matriptase, Keratinocyte, proteolytic
Abstract: Hepatocyte growth factor (HGF) has been shown to have multiple effects on the wound healing process. Several in vitro and ex vivo models using HGF have been shown to promote wound healing. The expression of HGF and its receptor cMet are different in chronic and acute wounds. HGF treatments in chronic wounds have not lived up to the expectations of the in vitro and ex vivo models. This review looks at the different expression of the HGF receptor and HGF agonists in chronic wounds compared to acute wounds. This aberrant expression may have a value in identifying early the wounds at risk of becoming chronic. A greater understanding of HGF and HGF agonists expression will have a direct implication for a protein engineering approach to the management of chronic wounds.
Export Options
About this article
Cite this article as:
Conway Kevin, HGF and HGF Agonists, Expression in Wound and Potential Role in the Management of Wound Healing, Current Signal Transduction Therapy 2011; 6 (2) . https://dx.doi.org/10.2174/157436211795659919
DOI https://dx.doi.org/10.2174/157436211795659919 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neuroimaging Features of Acquired Metabolic and Toxic Encephalopathies
Current Medical Imaging Design and Synthesis of Novel Thiosemicarbazones as Potent Anti-breast Cancer Agents
Letters in Drug Design & Discovery CASC15: A Tumor-Associated Long Non-Coding RNA
Current Pharmaceutical Design Biological Abilities of Rice Bran-Derived Antioxidant Phytochemicals for Medical Therapy
Current Topics in Medicinal Chemistry Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases
Mini-Reviews in Medicinal Chemistry The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma
Current Pharmaceutical Design QSAR Study of Androstenedione Analogs as Aromatase Inhibitors
Letters in Drug Design & Discovery Extracellular Proteases as Targets for Drug Development
Current Protein & Peptide Science Nanocarriers for Tracking and Treating Diseases
Current Medicinal Chemistry Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Features Identification for Phenotypic Classification Based on Genes and Gene Pairs
Current Bioinformatics A Review on the Prevalence of Depression in Malaysia
Current Psychiatry Reviews Patent Selections
Recent Patents on DNA & Gene Sequences SVM Kernel and Genetic Feature Selection Based Automated Diagnosis of Breast Cancer
Recent Advances in Computer Science and Communications Coffea arabica Bean Extracts and Vitamin C: A Novel Combination Unleashes MCF-7 Cell Death
Current Pharmaceutical Biotechnology Cancer Stem-Cells Patents in the Context of their Therapeutic Purposes: Exploring the Latest Trends (2011-2015)
Recent Patents on Regenerative Medicine Gold Nanostructure: Fabrication, Surface Modification, Targeting Imaging, and Enhanced Radiotherapy
Current Nanoscience Advances in Quantitative Mass Spectrometry Analysis: Weighing in on Isotope Coding and Label-Free Approaches for Expression and Functional Proteomics
Current Analytical Chemistry Meet Our Editorial Board Member
The Natural Products Journal A Comparison of Physicochemical Property Profiles of Marketed Oral Drugs and Orally Bioavailable Anti-Cancer Protein Kinase Inhibitors in Clinical Development
Current Topics in Medicinal Chemistry