Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases

Title: Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases

Volume: 9 Issue: 6

Author(s): B. Severino, V. Santagada, E. Perissutti, F. Fiorino, F. Frecentese, F. De Angelis, A. Esposito and G. Caliendo

Affiliation:

Keywords: Protease activated receptors, inflammation, agonist, antagonist, peptide-mimetic, small-molecule

Abstract: Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.

Cite this article as:

Severino B., Santagada V., Perissutti E., Fiorino F., Frecentese F., De Angelis F., Esposito A. and Caliendo G., Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases, Mini-Reviews in Medicinal Chemistry 2009; 9 (6) . https://dx.doi.org/10.2174/138955709788452711