Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities

Title: Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities

Volume: 5 Issue: 6

Author(s): U. Salma, Imtiaz-ud-Din, M. Mazhar and Khalid Mohammed Khan

Affiliation:

Keywords: Germatranes, diethyltin, tribenzyltin, spectroscopy, antileishmanial activity

Abstract: Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO]4-nSnR2 n, where n = 2, R2 = C2H5 (1-5); R1 = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R2 = CH2C6H5 (6- 8), R1 = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mossbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.

Cite this article as:

Salma U., Imtiaz-ud-Din , Mazhar M. and Khan Mohammed Khalid, Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities, Medicinal Chemistry 2009; 5 (6) . https://dx.doi.org/10.2174/157340609790170489