Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications

Title: Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications

Volume: 1 Issue: 2

Author(s): Takahiro Kubota

Affiliation:

Keywords: CYP2C9, CYP2C19, CYP2D6, thiopurine S-methyltransferase, glutathione S-transferase and sulfotransferase 1A1

Abstract: Different functional alleles for each subtype of cytochrome P450 (CYPs), thiopurine S-methyltransferase (TPMT), glutathione S-transferase (GST) and sulfotransferase (SULT) enzymes, have been identified. In this review, the genetic polymorphisms of drug-metabolizing enzymes in the Japanese population and their effects on metabolic activity are described in detail.

Cite this article as:

Kubota Takahiro, Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications, Drug Metabolism Letters 2007; 1 (2) . https://dx.doi.org/10.2174/187231207780363679