An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium

Title:An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium

Volume: 12 Issue: 10

Author(s): Faiza Boukezzoula, Taoues Boumoud, Boudjemaa Boumoud and Abdelmadjid Debache

Affiliation:

Keywords: Aqueous medium, ionic liquid, multicomponent reactions, octyltriphenylphosphonium bromide, pyranopyrazoles, rate enhancement, triphenylphosphine.

Abstract: The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, herein, an efficient and high yielding four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aromatic aldehydes using octyltriphenylphosphonium bromide as an effective and recoverable catalyst and water as solvent under mild reaction conditions.

Cite this article as:

Boukezzoula Faiza, Boumoud Taoues, Boumoud Boudjemaa and Debache Abdelmadjid, An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150924001127