The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Title: The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Volume: 16 Issue: 12

Author(s): Qing-Shan Fu, Ai-Xin Song, Su-Xia Li and Hong-Yu Hu

Affiliation:

Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

Abstract: Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

Cite this article as:

Fu Qing-Shan, Song Ai-Xin, Li Su-Xia and Hu Hong-Yu, The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein, Protein & Peptide Letters 2009; 16 (12) . https://dx.doi.org/10.2174/092986609789839386