The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor

Title: The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor

Volume: 6 Issue: 6

Author(s): Yepeng Luan, Xuejian Wang, Huawei Zhu, Xianjun Qu, Hao Fang and Wenfang Xu

Affiliation:

Keywords: Aminopeptidase N, Bestatin, N, N-dimethyl ethanolamine, A549, ES-2, HL-60

Abstract: Aminopeptidase N (APN) is a ubiquitous enzyme overexpressed on the epithelium of tumor and plays an important role in angiogenesis and metastasis of tumor. Bestatin acting as an inhibitor of Aminopeptidase N and B is used in the ancillary treatment of cancer. In this paper, we designed, synthesized a derivative of Bestatin (LYP), and evaluated the activity of it which exhibited better efficacy than Bestain in vitro and vivo.

Cite this article as:

Luan Yepeng, Wang Xuejian, Zhu Huawei, Qu Xianjun, Fang Hao and Xu Wenfang, The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor, Letters in Drug Design & Discovery 2009; 6 (6) . https://dx.doi.org/10.2174/157018009789057535