Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles

Title: Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles

Volume: 6 Issue: 6

Author(s): Laura Scarone, Jose Fajardo, Jenny Saldana, Laura Dominguez, Pablo Esposito, Sylvia Demastteis, Peter Wipf, Eduardo Manta and Gloria Serra

Affiliation:

Keywords: Bis-1, 3-azoles, Anthelmintic, Cytotoxic, Bengazoles

Abstract: Using different heterocycle formation methodologies (Deoxo-Fluor, DAST, POCl3, TosMIC), [2,5]bis-1,3- azoles were prepared as stable analogs of bengazoles, a family of potent anthelmintic marine natural products. The cytotoxic activity of these heterocycles and their precursors on HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis were evaluated.

Cite this article as:

Scarone Laura, Fajardo Jose, Saldana Jenny, Dominguez Laura, Esposito Pablo, Demastteis Sylvia, Wipf Peter, Manta Eduardo and Serra Gloria, Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles, Letters in Drug Design & Discovery 2009; 6 (6) . https://dx.doi.org/10.2174/157018009789057553