Abstract
Isoflavonoids containing a perfluoroalkylsulfonyloxy group were synthesized by perfluoroalkylsulfonylation of hydroxyisoflavones. The reaction showed high regioselectivity. Inhibitory effects of the synthesized isoflavones against proliferation of HL-60 and BEL-7402 cells were tested in vitro. Two isoflavones displayed strong inhibitory effect on HL- 60 cells.
Keywords: Isoflavone, perfluoroalkylsulfonate, regioselectivity, HL-60
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