Abstract
Isoflavonoids containing a perfluoroalkylsulfonyloxy group were synthesized by perfluoroalkylsulfonylation of hydroxyisoflavones. The reaction showed high regioselectivity. Inhibitory effects of the synthesized isoflavones against proliferation of HL-60 and BEL-7402 cells were tested in vitro. Two isoflavones displayed strong inhibitory effect on HL- 60 cells.
Keywords: Isoflavone, perfluoroalkylsulfonate, regioselectivity, HL-60
Letters in Organic Chemistry
Title: Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60
Volume: 6 Issue: 5
Author(s): Hongqi Li and Ye Jin
Affiliation:
Keywords: Isoflavone, perfluoroalkylsulfonate, regioselectivity, HL-60
Abstract: Isoflavonoids containing a perfluoroalkylsulfonyloxy group were synthesized by perfluoroalkylsulfonylation of hydroxyisoflavones. The reaction showed high regioselectivity. Inhibitory effects of the synthesized isoflavones against proliferation of HL-60 and BEL-7402 cells were tested in vitro. Two isoflavones displayed strong inhibitory effect on HL- 60 cells.
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Cite this article as:
Li Hongqi and Jin Ye, Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60, Letters in Organic Chemistry 2009; 6 (5) . https://dx.doi.org/10.2174/157017809788681257
DOI https://dx.doi.org/10.2174/157017809788681257 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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