Generic placeholder image

Current Reviews in Clinical and Experimental Pharmacology

Editor-in-Chief

ISSN (Print): 2772-4328
ISSN (Online): 2772-4336

Review Article

Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases

Author(s): Joyce T.S. Li, Kam L. Hon*, Alexander K.C. Leung and Vivian W.Y. Lee

Volume 16, Issue 3, 2021

Published on: 16 October, 2020

Page: [239 - 246] Pages: 8

DOI: 10.2174/1574884715666201016122612

Price: $65

conference banner
Abstract

Background: Green tea has been extensively studied for its potential health benefits against diseases, such as cancers, cognitive degenerative diseases, and cardiovascular diseases.

Methods: The authors undertook a structured search of peer-reviewed research articles from three databases including PubMed, Embase, and Ovid MEDLINE. Recent and up-to-date studies relevant to the topic were included.

Results: Green tea extract exerts its functions by interacting with multiple signalling pathways in human cells. Protein tyrosine kinase is one of the examples. Abnormal activation of tyrosine kinase is observed in some tumour cells. Green tea extract inhibits phosphorylation, reduces expression, or attenuates downstream signalling of epidermal growth factor receptor, insulin-like growth factor receptor, vascular endothelial growth factor receptor, and non-receptor tyrosine kinase. Combination of green tea extract with tyrosine kinase inhibitors may provide synergistic effects by overcoming acquired resistance.

Conclusion: Green tea extract can affect multiple receptor targets. In the current review, we discuss the pharmacological mechanisms of green tea on tyrosine kinases and their implications on common diseases.

Keywords: Cancer, green tea, tyrosine kinase, targeted therapy, multiple signalling pathways, synergistic effects.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy