Synthesis and Hydroxyapatite Binding Activity of Bisphosphonate-Statin Conjugates (SUPPLEMENTAL FILE)

Guangyu      Xu; Gaolei      Zuo; Shihua      Zhong; Wei      Zhang

doi:10.2174/157017809788681356

Abstract

To develop a methodology for delivering anabolic agents statins to bone, a bone targeting bisphosphonate was used as a carrier of drugs. Four statin-bisphosphonate conjugates were synthesized and examined for their bone mineral affinity in vitro by hydroxyapatite absorption method. The conjugates showed high binding activity with HAP, implying the modified statins possess the potential of bone targeting property.

Keywords: Statins, bisphosphonates, conjugate, bone targeting, hydroxyapatite

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Letters in Organic Chemistry

Title: Synthesis and Hydroxyapatite Binding Activity of Bisphosphonate-Statin Conjugates (SUPPLEMENTAL FILE)

Volume: 6 Issue: 5

Author(s): Guangyu Xu, Gaolei Zuo, Shihua Zhong and Wei Zhang

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Keywords: Statins, bisphosphonates, conjugate, bone targeting, hydroxyapatite

Abstract: To develop a methodology for delivering anabolic agents statins to bone, a bone targeting bisphosphonate was used as a carrier of drugs. Four statin-bisphosphonate conjugates were synthesized and examined for their bone mineral affinity in vitro by hydroxyapatite absorption method. The conjugates showed high binding activity with HAP, implying the modified statins possess the potential of bone targeting property.

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Xu Guangyu, Zuo Gaolei, Zhong Shihua and Zhang Wei, Synthesis and Hydroxyapatite Binding Activity of Bisphosphonate-Statin Conjugates (SUPPLEMENTAL FILE), Letters in Organic Chemistry 2009; 6 (5) . https://dx.doi.org/10.2174/157017809788681356