Abstract
The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding processes, causing decreased viral infectivity. This review describes the structure and function of the HIV-1 CA and latest progress in the discovery of HIV-1 CA inhibitors.
Keywords: HIV-1, AIDS, capsid inhibitor, antiviral agents, CA-N, CA-C, mutation
Mini-Reviews in Medicinal Chemistry
Title: Capsid (CA) Protein as a Novel Drug Target: Recent Progress in the Research of HIV-1 CA Inhibitors
Volume: 9 Issue: 4
Author(s): Jiyan Zhang, Xinyong Liu and Erik De Clercq
Affiliation:
Keywords: HIV-1, AIDS, capsid inhibitor, antiviral agents, CA-N, CA-C, mutation
Abstract: The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding processes, causing decreased viral infectivity. This review describes the structure and function of the HIV-1 CA and latest progress in the discovery of HIV-1 CA inhibitors.
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Cite this article as:
Zhang Jiyan, Liu Xinyong and De Clercq Erik, Capsid (CA) Protein as a Novel Drug Target: Recent Progress in the Research of HIV-1 CA Inhibitors, Mini-Reviews in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/138955709787847958
DOI https://dx.doi.org/10.2174/138955709787847958 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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