Abstract
A facile and efficient one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using a variety of aldehydes, 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, ethyl acetoacetate, and ammonium acetate in the presence of potassium dodecatungstocobaltate trihydrate [K5CoW12O40. 3H2O] as a heterogeneous catalyst in a solvent-free media at 90 °C is described herein . The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times (10-25 min.), milder conditions and the catalyst exhibited remarkable reusability.
Keywords: Potassium dodecatungstocobaltate.trihydrate, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, solventfree media, polyhydroquinoline reusability
Letters in Organic Chemistry
Title: A Facile Synthesis of Polyhydroquinoline Derivatives via the Hantzsch Reaction Under Solvent Free-Conditions Using Potassium Dodecatungsto Cobaltate Trihydrate (K5CoW12O40.3H2O)
Volume: 5 Issue: 1
Author(s): Lingaiah Nagarapu, Satyender Apuri, Subhashini Gaddam, Rajashaker Bantu, Venu C. Mahankhali and Srinivas Kantevari
Affiliation:
Keywords: Potassium dodecatungstocobaltate.trihydrate, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, solventfree media, polyhydroquinoline reusability
Abstract: A facile and efficient one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using a variety of aldehydes, 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, ethyl acetoacetate, and ammonium acetate in the presence of potassium dodecatungstocobaltate trihydrate [K5CoW12O40. 3H2O] as a heterogeneous catalyst in a solvent-free media at 90 °C is described herein . The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times (10-25 min.), milder conditions and the catalyst exhibited remarkable reusability.
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Nagarapu Lingaiah, Apuri Satyender, Gaddam Subhashini, Bantu Rajashaker, Mahankhali C. Venu and Kantevari Srinivas, A Facile Synthesis of Polyhydroquinoline Derivatives via the Hantzsch Reaction Under Solvent Free-Conditions Using Potassium Dodecatungsto Cobaltate Trihydrate (K5CoW12O40.3H2O), Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330162
DOI https://dx.doi.org/10.2174/157017808783330162 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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