Synthesis and Antibacterial Activity of New (2,3-dioxo-indolin-1-yl) acetamides

Title: Synthesis and Antibacterial Activity of New (2,3-dioxo-indolin-1-yl) acetamides

Volume: 5 Issue: 1

Author(s): P. Martin, R. Bouhfid, N. Joly, F. Ohmani, E. M. Essassi, V. Lequart, J. Banoub, K. Kheddid, R. Charof and M. Massoui

Affiliation:

Keywords: Isatin, acetamide, tertiary amide, in vitro biological activity

Abstract: The synthesis of a novel series of isatin derivatives bearing an acetamide group is described. These 2-(2,3- dioxo-indolin-1-yl)acetamide derivatives were synthesized by N-carboxymethylation of isatin followed by conversion of the carboxylic acid function into a tertiary amide. In a preliminary study, this series of compounds were tested in vitro for their biological activity, against various strains of bacteria.

Cite this article as:

Martin P., Bouhfid R., Joly N., Ohmani F., Essassi M. E., Lequart V., Banoub J., Kheddid K., Charof R. and Massoui M., Synthesis and Antibacterial Activity of New (2,3-dioxo-indolin-1-yl) acetamides, Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330199