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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

APP-Based Neuroprotective Strategies

Author(s): Dale E. Bredesen and Shahrooz Rabizadeh

Volume 4, Issue 5, 2007

Page: [541 - 543] Pages: 3

DOI: 10.2174/156720507783018253

Price: $65

Abstract

While much of the focus on Alzheimers disease therapeutics has been directed at beta-amyloid peptide or at cholinergic synaptic transmission, recent data suggest that targeting signal transduction by the amyloid precursor protein (APP) itself may be an alternative approach with significant potential [1]. Here we discuss the possibility that APPmediated signal transduction, downstream from amyloid-beta peptide production itself, may be an appropriate therapeutic target in Alzheimers disease.

Keywords: amyloid precursor protein interactors, Alzheimers disease, degenerating neuron, misfolded proteins, caspase


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