MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review

Title:MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review

Volume: 14 Issue: 8

Author(s): Hamidreza Maroof, Ali Salajegheh, Robert A. Smith and Alfred K.-Y. Lam

Affiliation:

Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.

Abstract: Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.

Cite this article as:

Maroof Hamidreza, Salajegheh Ali, A. Smith Robert and K.-Y. Lam Alfred, MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review, Current Cancer Drug Targets 2014; 14 (8) . https://dx.doi.org/10.2174/1568009614666141020100337