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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M. M. Pinto

Volume 13, Issue 10, 2013

Page: [1582 - 1589] Pages: 8

DOI: 10.2174/1871520613666131125122857

Price: $65

Abstract

Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.

Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.


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