Abstract
The use of natural compounds has recently been reconsidered in modern clinical practice. A further advancement of these compounds is represented by the possibility of using innovative drug delivery systems that can improve the biopharmaceutical features of the delivered compounds. This review examines the recent developments in the field of delivery of natural drugs belonging to several therapeutic classes. In particular, the examined therapeutic classes are: antitumoral drugs, i.e. paclitaxel, doxorubicin, tea catechins and hypericin; anti-infective drugs, i.e. Melaleuca alternifolia and Artemisia arborescens L.; and antinflammatory/antioxidant drugs, i.e. cannabinoids and glycyrrhizinates used for topical application. In this review we highlight the utility of a suitable drug delivery system to improve the biopharmaceutical aspects of these drugs. The examined carriers are: vesicular carriers (liposomes, Ethosomes®, ultradeformable liposomes), nano- and microparticles, innovative gels, microemulsions.
Keywords: Natural compounds, antitumoral drugs, anti-infective drugs, antiinflammatory drugs, drug delivery systems, vesicles, nanoparticles, microemulsions, cyclodextrins
Current Bioactive Compounds
Title: Innovative Drug Delivery Systems for the Administration of Natural Compounds
Volume: 3 Issue: 4
Author(s): Donatella Paolino, Donato Cosco, Felisa Cilurzo and Massimo Fresta
Affiliation:
Keywords: Natural compounds, antitumoral drugs, anti-infective drugs, antiinflammatory drugs, drug delivery systems, vesicles, nanoparticles, microemulsions, cyclodextrins
Abstract: The use of natural compounds has recently been reconsidered in modern clinical practice. A further advancement of these compounds is represented by the possibility of using innovative drug delivery systems that can improve the biopharmaceutical features of the delivered compounds. This review examines the recent developments in the field of delivery of natural drugs belonging to several therapeutic classes. In particular, the examined therapeutic classes are: antitumoral drugs, i.e. paclitaxel, doxorubicin, tea catechins and hypericin; anti-infective drugs, i.e. Melaleuca alternifolia and Artemisia arborescens L.; and antinflammatory/antioxidant drugs, i.e. cannabinoids and glycyrrhizinates used for topical application. In this review we highlight the utility of a suitable drug delivery system to improve the biopharmaceutical aspects of these drugs. The examined carriers are: vesicular carriers (liposomes, Ethosomes®, ultradeformable liposomes), nano- and microparticles, innovative gels, microemulsions.
Export Options
About this article
Cite this article as:
Paolino Donatella, Cosco Donato, Cilurzo Felisa and Fresta Massimo, Innovative Drug Delivery Systems for the Administration of Natural Compounds, Current Bioactive Compounds 2007; 3 (4) . https://dx.doi.org/10.2174/157340707783220301
DOI https://dx.doi.org/10.2174/157340707783220301 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Emerging Role of Mucins in Epithelial to Mesenchymal Transition
Current Cancer Drug Targets One Hundred Faces of Cyclopamine
Current Pharmaceutical Design Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer
Current Medicinal Chemistry Morphological and Functional Characteristic of Senescent Cancer Cells
Current Drug Targets Current Constructs and Targets in Clinical Development for Antibody- Based Cancer Therapy
Current Drug Targets Review of and Perspectives on the Toxicology of Graphene-based Materials
Current Drug Metabolism Survivin as a Prognostic/Predictive Marker and Molecular Target in Cancer Therapy
Current Medicinal Chemistry Updates of mTOR Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Tankyrases: Structure, Function and Therapeutic Implications in Cancer
Current Pharmaceutical Design Stress Related Neuroendocrine Influences in Ovarian Cancer
Current Cancer Therapy Reviews Antiangiogenic Agents in the Treatment of HER2-Negative Metastatic breast Cancer: A Brief Review
Current Angiogenesis (Discontinued) HLA-G Expression in Cancers: Potential Role in Diagnosis, Prognosis and Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts
Current Drug Targets Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design Role of PARP Inhibitors in Cancer Biology and Therapy
Current Medicinal Chemistry The Plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-regulating NFIX.
Current Molecular Medicine Cancer Regulator MicroRNA: Potential Relevance in Diagnosis, Prognosis and Treatment of Cancer
Current Medicinal Chemistry miRNAs as Modulators of Cholesterol in Breast Cancer Stem Cells: An Approach to Overcome Drug Resistance in Cancer
Current Drug Targets Specific Nutritional Supplement (Supportan<sup>®</sup>) in the Supportive Care of the Radio-Chemotherapy Treatment of Head and Neck Cancers: Biochemical Parameters. Preliminary Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Histone Modifications, Stem Cells and Prostate Cancer
Current Pharmaceutical Design