Review in Quantitative Structure Activity Relationships on Lipoxygenase Inhibitors

Pontiki      Eleni; Hadjipavlou-Litina      Dimitra

doi:10.2174/1389557033487999

Abstract

This paper reviews and evaluates all the published QSAR treatments of LOX inhibitors. This reveals that in almost all cases, the clog P parameter plays an important part in the QSAR relationships. In some cases the steric factors (B1, B5 and L) as well as the overall molar refractivity (CMR) or the substitutents molar refractivity (MR) are important. Electronic effects except for the Hammets constant θ, are comparatively unimportant. The study shows that log P as calculated from the Clog P program is suitable for this form of QSAR study. Log Po of 2.77-3.76 was found to be ideal, for the biological response.

Keywords: qsar, lox inhibitors, lipophilicity, steric factors, electronic effects

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