Abstract
N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
Keywords: bicyclo decanes, rhodium carbenoids, aryllead triacetates, ring-closing metathesis, multi-drug resistance
Current Organic Synthesis
Title: Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
Volume: 1 Issue: 1
Author(s): Carmen Avendano and J. Carlos Menendez
Affiliation:
Keywords: bicyclo decanes, rhodium carbenoids, aryllead triacetates, ring-closing metathesis, multi-drug resistance
Abstract: N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
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Cite this article as:
Avendano Carmen and Menendez Carlos J., Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures, Current Organic Synthesis 2004; 1 (1) . https://dx.doi.org/10.2174/1570179043485439
DOI https://dx.doi.org/10.2174/1570179043485439 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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