Abstract
A series of new chiral 2-(6,8-dichloro-4-methyl-1,1,3-trioxo-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-yl) carboxylic acids 7a-g containing the chiral amino acid residue were synthesized by adopting the chemical transformations, which have not affected the chirality of the amino acid residue. No significant racemization of the chiral centre was observed during the synthesis of enantiomeric benzothiadiazine 1,1-dioxide derivatives from the corresponding D and L amino acids. Structures of all the newly synthesized compounds were determined by analytical and spectral data.
Keywords: Chiral benzothiadiazine-1, 1-dioxide carboxylic acids, D and L- amino acid derivatives, N-methylation, esterification, hydrolysis
Letters in Organic Chemistry
Title: Synthesis of Chiral 2-(6,8-dichloro-4-methyl-1,1,3-trioxo-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-yl) Carboxylic Acids Derived from Enantiomeric Amino Acids
Volume: 4 Issue: 6
Author(s): Imtiyaz Ahmed Khazi and Young-Sik Jung
Affiliation:
Keywords: Chiral benzothiadiazine-1, 1-dioxide carboxylic acids, D and L- amino acid derivatives, N-methylation, esterification, hydrolysis
Abstract: A series of new chiral 2-(6,8-dichloro-4-methyl-1,1,3-trioxo-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-yl) carboxylic acids 7a-g containing the chiral amino acid residue were synthesized by adopting the chemical transformations, which have not affected the chirality of the amino acid residue. No significant racemization of the chiral centre was observed during the synthesis of enantiomeric benzothiadiazine 1,1-dioxide derivatives from the corresponding D and L amino acids. Structures of all the newly synthesized compounds were determined by analytical and spectral data.
Export Options
About this article
Cite this article as:
Imtiyaz Ahmed Khazi and Young-Sik Jung , Synthesis of Chiral 2-(6,8-dichloro-4-methyl-1,1,3-trioxo-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-yl) Carboxylic Acids Derived from Enantiomeric Amino Acids, Letters in Organic Chemistry 2007; 4 (6) . https://dx.doi.org/10.2174/157017807781467641
DOI https://dx.doi.org/10.2174/157017807781467641 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial: Advances in Understanding Alzheimer's Disease, and the Contributions of Current Alzheimer Research: Ten Years on and Beyond
Current Alzheimer Research <i>In-silico</i> Prediction of the Beta-carboline Alkaloids Harmine and Harmaline as Potent Drug Candidates for the Treatment of Parkinson’s disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Towards Alzheimers Disease Vaccination
Mini-Reviews in Medicinal Chemistry Primary Antiphospholipid Syndrome and Pulmonary Hypertension
Current Pharmaceutical Design Pre-Dementia Diagnosis of Alzheimers Disease: Translating Clinicobiologic Research into Practice
Current Psychiatry Reviews The Current Role of Statin Therapy in the Treatment of Atrial Fibrillation
Cardiovascular & Hematological Agents in Medicinal Chemistry Correlation between Changes of FDG-PET Findings and those of Mini- Mental Status Examination Scores in Patients with Moderate Alzheimer’s Disease: Usefulness of Stereotactic Extraction Estimation
Current Molecular Imaging (Discontinued) Possible Use of Autologous Stem Cell Therapies for Alzheimers Disease
Current Alzheimer Research Blood-based Amyloid and Tau Biomarker Tests For Alzheimer’s Disease
Neuroscience and Biomedical Engineering (Discontinued) Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke
CNS & Neurological Disorders - Drug Targets Hyperhomocysteinemia in Movement Disorders: Current Evidence and Hypotheses
Current Vascular Pharmacology Treatment of Mild Cognitive Impairment (MCI)
Current Alzheimer Research Determinants of Paraoxonase 1 Status: Genes, Drugs and Nutrition
Current Medicinal Chemistry A High-Throughput Screening Assay for Determining Cellular Levels of Total Tau Protein
Current Alzheimer Research The Relationship Between Plasma Aβ Levels, Cognitive Function and Brain Volumetrics: Sydney Memory and Ageing Study
Current Alzheimer Research Hereditary Haemorrhagic Teleangiectasia: Diagnostic Imaging of Visceral Involvement
Current Pharmaceutical Design Anti-Inflammatory Drugs in Psychiatry
Inflammation & Allergy - Drug Targets (Discontinued) Pathological Reorganization of NMDA Receptors Subunits and Postsynaptic Protein PSD-95 Distribution in Alzheimer’s Disease
Current Alzheimer Research Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease
Current Alzheimer Research Pre-CKD- Do we Need Another Hero?
Current Vascular Pharmacology